We welcome you to our myelodysplastic syndrome (MDS) treatment center at the Albert Einstein College of Medicine and Montefiore Medical Center. We have a dedicated team of experienced physicians, nurses, study coordinators, and pharmacists that will help you in the treatment of your condition. We offer standard as well as many investigational treatments for MDS. --Dr. Amit Verma, Head of MDS program

What is MDS?

Myelodysplastic syndromes are diseases of the blood and bone marrow. These diseases are characterized by low blood counts. Normally, the bone marrow makes blood stem cells that develop into mature blood cells over time. The stem cells develops into one of three types of mature blood cells:

In myelodysplastic syndromes, the blood stem cells do not mature into healthy red blood cells, white blood cells, or platelets. In addition, the cells in the blood and bone marrow (also called”myelo”) usually look abnormal (or “dysplastic”), hence the name “myelodysplastic” syndromes.

Each year more than 15,000 new cases of MDS are diagnosed in the United States. Patients tend to be elderly at the time of diagnosis, although people of any age can develop the disease. MDS is classified as either primary (also called de novo) — disease that has no known cause — or secondary (also called treatment-related) MDS. Treatment-related MDS is caused by previous treatment with chemotherapy or radiation therapy, which is given for a previously diagnosed cancer.

Previously, MDS was commonly referred to as a preleukemic condition (and it is still sometimes called preleukemia) because some people with MDS develop acute leukemia as a complication of the disease. However, most patients with MDS will never develop acute leukemia. In a third of MDS cases, over time, very immature bone marrow cells called blasts may increase in number and fill the bone marrow, displacing the normal red and white blood cells and platelets that are produced there. This overgrowth of blasts, if severe enough, is called acute leukemia.

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